Because phorbol is highly water-soluble, you don’t even want to be standing under a manchineel when it’s raining — the raindrops carrying the diluted sap can still severely burn your skin. As explained by the Florida Institute of Food and Agricultural Sciences, all parts of manchineel are extremely poisonous, and “interaction with and ingestion of any part of this tree may be lethal”. It’s native to the tropical parts of southern North America, as well as Central America, the Caribbean, and parts auto parts bearings Manufacturers of northern South America.. The fruit in question belonged to the manchineel tree (Hippomane mancinella), sometimes referred to as beach apple or poison guava.Scattered amongst the coconuts and mangoes on the beach, Strickland and her friend found some sweet-smelling green fruit that looked much like small crabapples. Both foolishly decided to take a bite, and within moments the pleasant, sweet taste was overwhelmed by a peppery, burning feeling and an excruciating tightness in the throat that gradually got so bad they could barely swallow.According to the Guinness World Records, the manchineel tree is, in fact, the most dangerous tree in the world. This sap contains a range of toxins, but it’s thought that the most serious reactions come from phorbol, an organic compound that belongs to the diterpene family of esters. On her first morning there, she went foraging for shells and corals in the white sand, when the holiday quickly took a turn for the worse. The tree produces a thick, milky sap, which oozes out of everything — the bark, the leaves and even the fruit — and can cause severe, burn-like blisters if it comes in contact with the skin.In 1999, radiologist Nicola Strickland went on a holiday to the Caribbean island of Tobago, a tropical paradise complete with idyllic, deserted beaches.The plant bears another name in Spanish, arbol de la muerte, which literally means “tree of death”.Manchineel belongs to the large and diverse Euphorbia genus, which also contains the decorative Christmas poinsettia.